منابع مشابه
p53 connects tumorigenesis and reprogramming to pluripotency
The tumor suppressor gene p53 prevents the initiation of tumor formation by inducing cell cycle arrest, senescence, DNA repair, and apoptosis. Recently, the absence or mutation of p53 was described to facilitate nuclear reprogramming. These findings suggest an influence of p53 on the de-differentiation process, and highlight the similarities between induction of pluripotency and tumor formation.
متن کاملp53 Prevents Entry into Mitosis with Uncapped Telomeres
Telomeres are protected by capping structures consisting of core protein complexes that bind with sequence specificity to telomeric DNA. In their absence, telomeres trigger a DNA damage response, materialized in accumulation at the telomere of damage response proteins, e.g., phosphorylated histone H2AX (gammaH2AX), into telomere-dysfunction-induced foci. Telomere uncapping occurs transiently in...
متن کاملAntibody-mediated p53 protein therapy prevents liver metastasis in vivo.
To evaluate the clinical efficacy of monoclonal antibody (mAb) 3E10 Fv antibody-mediated p53 protein therapy, an Fv-p53 fusion protein produced in Pichia pastoris was tested on CT26.CL25 colon cancer cells in vitro and in vivo in a mouse model of colon cancer metastasis to the liver. In vitro experiments showed killing of CT26.CL25 cells by Fv-p53 but not Fv or p53 alone, and immunohistochemica...
متن کاملMpl ligand prevents lethal myelosuppression by inhibiting p53-dependent apoptosis.
A single dose of Mpl ligand (Mpl-L) given immediately after lethal DNA-damaging regimens prevents the death of mice. However, the mechanism of this myeloprotection is unknown. The induction of p53-dependent apoptosis in response to DNA damage signals suggests that immediate administration of Mpl-L may inhibit p53-dependent apoptosis. This hypothesis was tested by administering a single injectio...
متن کاملNucleophosmin prevents p53 dependent apoptosis by blocking p53 migration to mitochondria
Bi-directional Regulation of the Human Manganese Superoxide Dismutase Gene Sanjit K. Dhar, Yong Xu, and Daret K. St. Clair† From Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 Running title: Dual regulation of MnSOD by p53 †Address correspondence to: Daret K. St. Clair, Ph. D. Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536. Tel: 1-859-25...
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ژورنال
عنوان ژورنال: Nature Reports Stem Cells
سال: 2009
ISSN: 1754-8705
DOI: 10.1038/stemcells.2009.112